تأثیر تمرینات ورزشی بر سطح فاکتور نوروتروفیک مشتق از مغز (BDNF) در سالمندان با و بدون بیماری: مطالعه فراتحلیل

نویسندگان

    امید ظفرمند گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه یاسوج، یاسوج، ایران
    فرناز ترابی * گروه تربیت بدنی و علوم ورزشی، دانشگاه پیام نور، تهران، ایران. f.torabi@pnu.ac.ir

کلمات کلیدی:

تمرین ورزشی, فاکتور نوروتروفیک مشتق از مغز, سالمند

چکیده

فاکتور نوروتروفیک مشتق از مغز (BDNF) پروتئینی حیاتی برای سلامت و عملکرد نورون‌هاست که در سالمندان، به‌ویژه افراد مبتلا به بیماری، کاهش می‌یابد و ممکن است باعث افت شناختی شود. ورزش می‌تواند سطح این فاکتور را افزایش دهد. هدف این پژوهش، گردآوری و تحلیل شواهد موجود برای ارزیابی اثر تمرینات ورزشی بر میزان BDNF در سالمندان با و بدون بیماری است انجام شده است. جست‌وجوی سیستماتیک در پایگاه‌های اطلاعاتی PubMed، Web of Science، Scopus، Magiran، Irandoc، NoorMags و SID برای شناسایی مقالات منتشرشده از آغاز تا فروردین ۱۴۰۴ (آوریل ۲۰۲۵) انجام گرفت. برای محاسبه اندازه اثر، تفاوت میانگین استانداردشده (SMD) همراه با فاصله اطمینان ۹۵درصد به کمک نرم‌افزار CMA2 برآورد شد. ناهمگونی میان مطالعات با آزمون I² بررسی گردید و سوگیری انتشار از طریق تحلیل بصری نمودار قیفی و آزمون ایگر ارزیابی شد. همچنین کیفیت مطالعات واردشده به فراتحلیل بر اساس چک‌لیست پدرو مورد سنجش قرار گرفت. در مجموع 33 مطالعه (با40 مداخله تمرین ورزشی) روی 1099 آزمودنی سالمند با و بدون بیماری فراتحلیل شدند و نتایج نشان داد مداخله تمرینات ورزشی در افراد سالمند با و بدون بیماری افزایش معنادار BDNF ]001/0 P= ،(326/1 الی 444/2)‌ 885/1 = [SMD نسبت به گروه شاهد همراه شد. نتایج فراتحلیل نشان داد که تمرینات ورزشی به‌طور قابل‌توجهی سطح BDNF را در سالمندان با و بدون و بیماری افزایش می‌دهد و این اثر نسبت به گروه کنترل معنادار است. این یافته‌ها تأکید می‌کنند که فعالیت بدنی می‌تواند یک راهکار مؤثر برای تقویت سلامت عصبی و شناختی در سالمندان باشد.

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ظفرمند ا.، و ترابی ف. (1404). تأثیر تمرینات ورزشی بر سطح فاکتور نوروتروفیک مشتق از مغز (BDNF) در سالمندان با و بدون بیماری: مطالعه فراتحلیل. طول عمر، 3(2)، 1-23. https://quarterlylongevity.com/index.php/longevity/article/view/62

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